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Greinke, Kansas City's No. 2 starter who was making his eighth start of the spring, allowed four runs and six hits in five innings to fall to 3-3 with a 9.21 ERA.
Rangers starter Vicente Padilla left after two innings because of slight stiffness in his right forearm.
Padilla allowed one run and two hits in his final spring tuneup. Padilla was originally scheduled for a four-inning stint, but he left after two as a precaution. Padilla, who led the team with 14 wins last season, is projected as Texas' No. 2 starter.
He's scheduled to start Wednesday night against Cleveland in the Rangers' second regular-season game after Kevin Millwood draws Monday's opening-day assignment against the Indians.
Manager Ron Washington expressed confidence that Padilla would make that start.
"When the bell rings, he'll be ready to go," Washington said. "I don't have any concerns about that."
Padilla threw seven innings in a minor league game on Monday, and he normally pitches on five days rest. Padilla thinks the lack of an extra day off might have caused the stiffness.
"It had been four days and I'd been throwing a lot," Padilla said. "It feels good. I'm ready to go."
Brandon McCarthy, projected as the Rangers' No. 3 starter, pitched the next four innings, allowing one run and three hits to improve to 4-0 in the spring.
Andruw Jones' two-run double in the seventh extended Texas' lead to 6-2.
Notes: Before the game, the Royals announced they outrighted 1B Ryan Shealy to Triple-A Omaha, leaving them at 30 players on the roster. Manager Trey Hillman said the final 25-man roster might not be announced until the Sunday deadline. ... The game was played at the home park of the Frisco RoughRiders, the Rangers' Double-A affiliate north of Dallas. ... The teams, which share a spring training facility in Surprise, Ariz., were playing for the eighth time this spring. They wrap up their exhibition schedule Saturday at the Rangers' home park in Arlington with Texas having won five. ... Greinke struck out the side in the fourth.
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